Application of micro-tomography and UV spectroscopy in structural analysis of pharmaceutical granules
نویسندگان
چکیده
Aims The X-ray micro-tomography (micro-CT) technique has been used to visualize the microstructure of pharmaceutical granules produced by high shear wet granulation and the dynamic evolution of porosity during granule dissolution. The combination of time-resolved micro-CT imaging with UV/VIS detection of the quantity dissolved made it possible to evaluate the effective diffusion coefficient of the active pharmaceutical ingredient (API) through the granule structure, and thus establish a quantitative structure–property relationship for dissolution.
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